Peptides and lipopeptides synthesis 

We offer a fast and high quality synthesis of compounds at a low prices.

• Short lead times
• Valuation in 24 hours
• High purity

• Custom peptide synthesis

  Lipopharm.pl laboratory offers custom peptide synthesis. Over 13 years of experience of Lipopharm.pl in the field of syntheses ensure fast and timely delivery of peptides on a scale from 2 mg to gram quantities and purity even about 97%.

  The peptides are obtained on solid support using Fmoc or Boc strategy. Long peptides (up to 30-40 amino acid residues long) are obtained using modern microwave peptide synthesizers. Large scale peptide synthesis is performed manually using Skiller 1 and Skiller 4 equipment.

  The peptides are purified using chromatographic methods (mainly RP-HPLC). In special cases, size exclusion chromatography and ion chromatography are used. To each peptide both HPLC chromatogram (purity) and mass spectra (identity confirmation) are attached.

  The peptides are obtained in the form of trifluoroacetate salts. It is possible to order peptides in the form of an acetate salt or hydrochloride. The successful conversion into the corresponding salt is confirmed by an ion chromatograph.

   

  Typical peptide modifications:

  - C-terminal amidation,

  - N-terminal acetylation,

  - acylation with fatty acid,

  - N-C cyclization,

  - multiple disulfide bonds,

  - biotinylation,

  - pegylation,

  - labeling with fluorescent dyes (FITC, RhB, ...),

  - D-amino acids,

  - isotope-labeled amino acids,

  - phosphorylated amino acids.

   

  Each order is priced individually. Price depends on quantity, purity and the complexity of the structure and properties of peptides. The waiting time is usually form 7 to 14 days. It is possible to deliver peptides in the express mode, even within 2-3 days.

Table of offered peptides

Full table of offered peptides

PBS

OPRACOWANIE NOWYCH FUNKCJONALNYCH, AKTYWNYCH BIOLOGICZNIE POWŁOK PRZEZNACZONYCH NA ELEMENTY WYPOSAŻENIA PLACÓWEK MEDYCZNYCH

• Instytut Metali Nieżelaznych – LIDER
• CERTECH Sp.z o.o.
• ALVO Spółka z ograniczoną odpowiedzialnością Sp. k
• Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego Polskiej Akademii Nauk
• LIPOPHARM.pl

POiG

• 1. Wrona A., Bilewska K., Lis M., Kamińska M., Olszewski T., Pajzderski P., Więcław G., Jaśkiewicz M., Kamysz W., Antimicrobial properties of protective coatings produced by plasma spraying technique. Surf. Coat. Technol. 318, 332-340 (2017).
• 2. Jorge P., Grzywacz D., Kamysz W., Lourenço A., Pereira M.O., Searching for new strategies against biofilm infections: Colistin-AMP combinations against Pseudomonas aeruginosa and Staphylococcus aureus single- and double-species biofilms. Plos One 12(3), e0174654 (2017).
• 3. Jaskiewicz M., Orlowska M., Olizarowicz G., Migon D., Grzywacz D., Kamysz W., Rapid Screening of Antimicrobial Synthetic Peptides. Int J Pept Res Ther 22(2), 155-161 (2016).
• 4. Pikula M., Zielinski M., Specjalski K., Baranska-Rybak W., Dawgul M., Langa P., Jassem E., Kamysz W., Trzonkowski P., In Vitro Evaluation of the Allergic Potential of Antibacterial Peptides: Camel and Citropin. Chem Biol Drug Des 87(4), 562-568 (2016).
• 5. Bochenska O., Rapala-Kozik M., Wolak N., Kamysz W., Grzywacz D., Aoki W., Ueda M., Kozik A., Inactivation of human kininogen-derived antimicrobial peptides by secreted aspartic proteases produced by the pathogenic yeast Candida albicans. Biol Chem 396(12), 1369-1375 (2015).
• 6. Bauer M., Maciejewska M., Dawgul M., Grzywacz D., Kamysz W., Activity of Antimicrobial Peptides Against Bacterial Biofilms Formed on Contact Lenses. J Pept Sci 20, S264-S265, Supplement: 1, Meeting Abstract: P247 (2014).
• 7. Bochenska O., Rapala-Kozik M., Wolak N., Kamysz W., Grzywacz D., Aoki W., Ueda M., Kozik A., Contribution of secreted aspartic proteases of pathogenic yeast Candida albicans to the neutralization of antimicrobial function of human high molecular weight kininogen. FEBS J 281, 735-736, Supplement: 1, Special Issue: SI,  Meeting Abstract: WED-349 (2014).
• 8. Salaga M., Polepally P.R., Sobczak M., Grzywacz D., Kamysz W., Sibaev A., Storr M., Do Rego J.C., Zjawiony J.K., Fichna J., Novel Orally Available Salvinorin A Analog PR-38 Inhibits Gastrointestinal Motility and Reduces Abdominal Pain in Mouse Models Mimicking Irritable Bowel Syndrome. J Pharmacol Exp Ther 350(1), 69-78 (2014).
• 9. Ostrowska K., Kamysz W., Dawgul M., Rozalski A., Synthetic Amphibian Peptides and Short Amino-Acids Derivatives Against Planktonic Cells and Mature Biofilm of Providencia stuartii Clinical Strains. Pol J Microbiol 63(4), 423-431 (2014).
• 10. Fichna J., Mazur M., Grzywacz D., Kamysz W., Perlikowska R., Piekielna J., Sobczak M., Salaga M., Toth G., Janecka A., Chen C.Q., Olczak J., Novel glycosylated endomorphin-2 analog produces potent centrally-mediated antinociception in mice after peripheral administration. Bioorg Med Chem Lett 23(24), 6673-6676 (2013).
• 11. Bras G., Bochenska O., Rapala-Kozik M., Guevara-Lora I., Faussner A., Kamysz W., Kozik A., Release of biologically active kinin peptides, Met-Lys-bradykinin and Leu-Met-Lys-bradykinin from human kininogens by two major secreted aspartic proteases of Candida parapsilosis. Peptides 48, 114-123 (2013).
• 12. Karkowska-Kuleta J., Kedracka-Krok S., Rapala-Kozik M., Kamysz W., Bielinska S., Karafova A., Kozik A., Molecular determinants of the interaction between human high molecular weight kininogen and Candida albicans cell wall: Identification of kininogen-binding proteins on fungal cell wall and mapping the cell wall-binding regions on kininogen molecule. Peptides 32(12), 2488-2496 (2011).
• 13. Sikorska E., Greber K., Rodziewicz-Motowidlo S., Szultka L., Lukasiak J., Kamysz W., Synthesis and antimicrobial activity of truncated fragments and analogs of citropin 1.1: The solution structure of the SDS micelle-bound citropin-like peptides. J Struct Biol 168(2), 250-258 (2009).
• 14. Baranska-Rybak W., Szultka L., Sokolowska-Wojdylo M., Naumiuk L., Nowicki R., Kamysz W., Roszkiewicz J., Are the superantigens producing Staphylococcus aureus strains more resistant to antimicrobial peptides? J Invest Dermatol 129, S16-S16 (2009).
• 15. Ciarkowski J., Mickiewicz B., Kamysz E., Kamysz W., Rodziewicz-Motowido S., New analogues of the antimicrobial gramicidin S. J Pept Sci 14(8), 99-99 Supplement: S (2008).